Besides CVD, developing a greater understanding of cellular LCAC pathogenesis will be informative for the disease processes of rare, but often lethal, fatty acid oxidation and carnitine metabolism disorders (Spiekerkoetter et al., 2009
Patients should not rush dose increases and should communicate with their prescribers if side effects are limiting their ability to maintain adequate nutrition or physical activity
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During this examination, the physician may also inquire about the patient's medical history, including any previous knee injuries or surgeries, which can provide additional context for the current symptoms
2.2.5 Metabolic reprogramming Metabolic reprogramming refers to the process in which cells, under specific physiological and pathological conditions, systematically adjust and transform their metabolic patterns to adapt to changes in the external environment and to meet their own needs for growth and differentiation, by engaging various bioenergetic routes, such as glucose utilization, lipid metabolism, and amino acid metabolism (Xia et al., 2021