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While nutrition and physical activity are important, they are not the only factors that influence body weight

Glycemic control of type 2 diabetic patients after short-term zinc supplementation

For example, semaglutide lowered kidney complications in people with type 2 diabetes and chronic kidney disease in a trial of more than 3,500 patients, and the FDA approved Ozempic for chronic kidney disease in people with type 2 diabetes in January 2025

So APOE4 is not a good thing