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In pre-clinical research, it is primarily studied for its effects on gastrointestinal healing, tendon and ligament repair, vascular growth (angiogenesis), and potential neuroprotective properties

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Hum Genet 138:13591377 Schiff MH, Jaffe JS, Freundlich B (2014) Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses 15 mg may be overcome with subcutaneous administration

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The correlation coefficient between the two protocols was 0.9967