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Many insurers now cover Wegovy and Zepbound for weight loss

Clinical trials show patients on metformin who added tirzepatide achieved 9-11 kg weight loss over 40 weeks, substantially more than metformin's typical 1-3 kg reduction alone

Tirzepatide is a dual GIP and GLP-1 receptor agonist approved by the FDA under the brand names Mounjaro and Zepbound

They include: Nausea the most commonly reported symptom, typically peaking in the first one to two weeks after a dose change Diarrhoea and constipation both can occur, sometimes alternating Vomiting less common than nausea but reported by some patients at higher doses Abdominal discomfort or bloating Diet-related side effects occur when patients eat too little, too quickly, or consume high-fat meals

Easier to measure small doses precisely