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This infers that acute/controlled activation of NRF2 protect against DI, whereas chronic activation, particularly due to complete genetic ablation of Keap1 , could be harmful

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As with other IDPs, FOXO disordered regions may adopt ordered conformations upon binding of cognate partners: a fusion peptide of regions CR2C and CR3 of FOXO3 has been shown to adopt helical conformation when bound to the CREB-binding protein (CBP) [46], while these regions are likely disordered when unbound

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