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Possible effects depend on the exact medication but may include: Pain, redness, itching, or swelling at the injection site Headache Fatigue Nausea or digestive symptoms Dizziness Changes in appetite Fluid retention Changes in blood sugar Changes in heart rate or blood pressure Hormonal effects Allergic or immune reactions For many newer peptides, the full side-effect profile and long-term risks are not known

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Most studies are rodent models

doi: 10.3390/nu10091203 133 GoriniFSabatinoLPingitoreAVassalleC

You may also notice appetite reduction, which is a desired effect for those using semaglutide oral options for weight control