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Metabolites associated with uremic symptoms in patients with CKD: findings from the chronic renal insufficiency cohort (CRIC) study

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HO-1, an Nrf2-regulated antioxidant factor, catalyzes heme degradation and releases anti-inflammatory mediators, thereby exerting anti-inflammatory effects 15

For oral semaglutide, the PIONEER 6 trial showed non-inferiority for cardiovascular safety, though it is important to note that Rybelsus does not have a specific licensed indication for cardiovascular risk reduction in the UK

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