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Renal and hepatic effects: Long-term or high-dose use has been associated in case reports with adverse effects on kidney and liver function

Also of note is that when the body is depleted of adequate amino acids, it cannot efficiently manufacture glutathione without destructing muscle tissue

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In the case of gastric reflux between meals (when not digesting food), I found it much more helpful to have a level teaspoon of bicarbonate of soda in a glass of water, which neutralises acids that may be caused by stomach bacteria, or bacteria from SIBO