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(There are several studies involving animals, but not human subjects.) What research does show is that people who are overweight tend to be low in vitamin B12

While true allergic reactions to B12 are exceptionally rare, they can present with various symptoms that might include joint discomfort alongside other systemic manifestations

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4 In a follow-up study, researchers found that supplementing with vitamins B12 and B9 (folic acid) may increase the risk of colon cancer

When AKT is inhibited, skeletal muscle glucose uptake and glycogen synthesis are impaired [103], implying that robust AKT signaling is necessary for GLP-1-dependent increases in skeletal muscle glycogen synthesis