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Finding the human and porcine peptide to have identical sequences, the team concluded 'GLP-1 (PG 78-107 amide) from the small intestine seems to be a new hormone with important functions in the control of metabolism and glucose turnover' (rskov, Bersani, Johnson)

In contrast, thyroxine (T4) may elicit pro-fibrotic effects through non-genomic signaling via integrin v3, activating Rho-dependent pathways that induce -SMA and p75 neurotrophin receptor (p75NTR) expression in HSCs (99)

LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al

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