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Subgroups and Placebo Response Prespecified subgroup analyses showed reductions in heavy drinking days among patients with severe alcohol use disorder and among those with 12 to 17 heavy drinking days at baseline

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The anteroposterior (AP) and craniocaudal (CC) diameters were measured, and the mean was used to calculate the cross-sectional area (CSA) using the following formula: CSA (cm 2 ) = ( AP CC)/4