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The substantial weight loss achieved with GLP-1 receptor agonists and dual GIP/GLP-1 agonistsapproximately 15% with semaglutide 2.4 mg (Wegovy) and up to 21% with higher doses of tirzepatide (Zepbound) in clinical trialsoccurs primarily through appetite suppression and reduced caloric intake rather than increased metabolic rate

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GLP-1s are designed for use in combination with a healthy lifestyle as part of a comprehensive medical weight loss program

In an emailed response to questions from CBC News, Health Canada said it had received four complaints in six months about adverse reactions in people who took unauthorized peptides

Advancements in oral and injectable formulations are improving patient compliance and convenience