Spinal microglial -endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain
Cross-sectional metagenomic and metabolomic cohorts consistently show a decrease in butyrate-producing taxa (e.g., Faecalibacterium, Roseburia) and an increase in mucin-degrading or pro-inflammatory genera (e.g., Akkermansia, some Enterobacteriaceae) across geographically diverse PD cohorts, with some taxa correlated with constipation, disease duration, and motor scores [57]
[DOI] [PubMed] [Google Scholar] 28.Malhotra A., Grunstein R.R., Fietze I., Weaver T.E., Redline S., Azarbarzin A., Sands S.A., Schwab R.J., Dunn J.P., Chakladar S., et al
Sometimes, persistent stress and fatigue may signal an underlying health issue
The epidermal growth factor receptor and the TLR signal transduction pathways may contribute to CNS remyelination and recovery of function induced by T4 (Zhang et al., 2016a, Santra et al., 2014)