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Loss of lean muscle mass is a well-publicized issue for people that rapidly lose weight on these drugs, and adequate protein intake is important

However, we mitigated the potential confounding effect of CAD through the use of MR analysis and by rigorously selecting genetic instruments that were strongly associated with GLP-1RAs, while excluding SNPs associated with CAD and other pleiotropic pathways

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L.GianniniD.VagagginiB.ContiI.MacchioniP.et al (2001)