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Multi-omics approaches, such as metabolomics to identify lipid peroxidation profiles and genomics to characterize polymorphisms in ferroptosis-regulating genes, may allow more accurate pathological classification

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While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation