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Future directions in research on free radicals and antioxidants As our understanding of free radicals and their role in disease pathology deepens, several promising avenues for future research emerge (Fig

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Recently, we demonstrated that the cyclolignan PPP inhibited phosphorylation of IGF-1R without interfering with insulin receptor activity (Girnita et al, 2004), as well as it reduced phosphorylated Akt, caused apoptosis and induced tumour regression in xenografted mice