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Starting at 1.0 mg significantly increases the risk of nausea, vomiting, and other gastrointestinal side effects

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Treatment continuation is generally recommended when: Vomiting is mild and intermittent rather than severe and persistent Symptoms are improving over time with supportive measures You are achieving good glycaemic control and other therapeutic benefits Dietary modifications and appropriate symptom management provide adequate relief You are able to maintain adequate hydration and nutrition In clinical practice, many patients who experience initial vomiting find that symptoms resolve within 4-8 weeks as tolerance develops

In clinical trials, it was found to lead to greater weight loss compared to other GLP-1 receptor agonists