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It may be reasonable to focus on whether the combination of GLP-1RAs and SGLT2is, which are expected to have complementary effects based on large-scale clinical trial results, can further reduce cardiovascular and renal events in patients with diabetes
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Scientific References Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade
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