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Yet, translating these mechanisms into next-generation therapiessuch as dual and triple incretin agonistsrequires a nuanced understanding of receptor dynamics, biased agonism, and tissue-specific signaling

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This is why allodynia associated with semaglutide use can persist for weeks or even months after dose reduction

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Therefore, we posit that this differential pharmacological properties may account for the observed discrepancy in experimental outcomes between the in vitro phagocytosis assays and in vivo tumor suppression models