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Dysphoria: A persistent sense of unhappiness or dissatisfaction replaces the euphoria previously induced by Vyvanse, leading to emotional distress

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This innovative approach has demonstrated impressive results in clinical studies, with participants experiencing substantial weight loss and improvements in overall metabolic health

Prior to naltrexone initiation: Ask about opioid use history or if currently on buprenorphine or methadone Administer a 0.4 mg IV naloxone challenge dose Will help to determine if naltrexone would precipitate withdrawal If no precipitated withdrawal occurs, proceed with treatment Start naltrexone treatment: Oral: Start with 50 mg PO naltrexone Injectable: Start with 380 mg IM naltrexone Discharge planning: If PO naltrexone is given, then discharge the patient with a prescription for up to 30 days (50 mg daily)