Mutants affected in the transport and degradation of glutathione and glutathione S-conjugates did not exhibit differences in their susceptibility to AITC While glutathione is synthesized in the chloroplast and the cytosol it is also present in the mitochondrion, nucleus and the apoplast, indicating the necessity of transport 56
Certain antibiotics, particularly those that may affect gastrointestinal function, require careful monitoring when used concurrently with this combination therapy
Recently, an in vitro study by Tyagi (1998) demonstrated that homocysteine (10 mol/L) induces human vascular smooth muscle cell proliferation and collagen expression
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GSH transport into mitochondria appears to be mediated in part by the dicarboxylate carrier (DIC, Slc25a10) and the oxoglutarate carrier (OGC, Slc25a11) (Lash, 2006), whereas transport into the nucleus probably occurs by passive diffusion through the nuclear pores
