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The DCCT study demonstrated that intensive insulin therapy in T1D significantly reduced the risk of DPN by 64% and cardiovascular autonomic neuropathy by 45% compared with conventional treatment, with these benefits persisting for over 13 years after the trial ended [60]

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The therapeutic targeting of HDL non-cholesterol cargo, quality, and function are emerging and gaining support, as HDL have many other biological properties that likely contribute to prevention of atherosclerosis and CVD (745)

Metabolic syndrome, chronic kidney disease, and cardiovascular disease: a dynamic and life-threatening triad