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While DAO and HNMT are the primary enzymes for histamine degradation, the liver processes the downstream metabolites and crucially, it regulates oestrogen, which has a critically important and bi-directional relationship with histamine

AI models integrating these variables could forecast expected weight loss and side effect risk, guiding treatment selection and dose titration

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10.2147/DDDT.S527687 46 MarchandA.BuckleyS.SchneuingA.PacesaM.EliaM.GainzaP.et al (2025)

Schedule I lists drugs or other substance that have a high potential for abuse have no accepted medical use in the United States, and do not have accepted safety guidelines for use