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Glucagon Reduction : Suppresses glucagon, a hormone that typically prompts the liver to produce excess glucose
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If symptoms are bothersome, remain at this dose for another week before increasing
Canagliflozin reduced the risk of the primary composite outcome (ESKD, doubling of serum creatinine, or renal or cardiovascular death) by 30% compared to placebo, with consistent effects across all prespecified subgroups [46]
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