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Astrocytes, the most abundant cell type in the CNS, possess diverse functions, including neurotransmitter cycling, formation and maintenance of the BBB, immune signaling, and regulation of neuronal synaptogenesis (Giovannoni and Quintana, 2020)
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The efficacy and safety of acetyl-l-carnitine (500 mg three times a day) versus methylcobalamin (0.5 mg three times a day) to treat diabetic peripheral neuropathy was assessed in a Chinese multicentre, randomised, parallel-group, double-blind, double-dummy, positive-controlled, non-inferiority phase II clinical trial