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Gut microbiota diversity is greatly dependent on various host factors including diet, human lifestyle, age, and environmental factors

In contrast, prescription GLP-1 agonists require medical approval and supervision

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However, some patients report sleep disturbances that may be indirectly related to gastrointestinal symptoms or metabolic changes during treatment

The semaglutide cohort ( n = 1470) compared with the non-GLP-1RA anti-obesity medications cohort ( n = 2784) was older, included more women, had a higher prevalence of severe obesity and obesity-associated comorbidities including T2DM and lower prevalence of adverse socioeconomic determinants of health, mental disorders, and substance use disorders