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In their work, Gu et al

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It has since been studied extensively as a model copper-carrier peptide, and is investigated for its role in skin and extracellular-matrix research, including work on collagen-related gene expression and fibroblast behaviour in cultured models

The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growth in vitro

These activities apply stress to the skeletal system, promoting bone strength and reducing age-related bone mass loss