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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation

Inflammatory conditions, particularly inflammatory bowel disease with elevated pro-inflammatory cytokines (TNF-, IL-1, IFN-), can suppress OCTN2 expression, reducing intestinal L-carnitine absorption (18)

Product Size: 1900ml

84 MoghaddamB.AdamsB.VermaA.DalyD

Mitochondrial dynamics shift, affecting fission-fusion balance and uncoupling protein expression[9]