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Injectable therapies
In another study in healthy and obese-diabetic animal models, allulose also elicited a GLP-1 release, reduced food intake and showed positive effects on glucose tolerance (Reference Iwasaki, Sendo and Dezaki17)
The table lists nausea of any grade at 25 to 48 percent in the SUSTAIN trials for semaglutide and 25 to 50 percent in the SURMOUNT trials for tirzepatide, calling both dose-dependent and typically resolving within four to eight weeks
Tirzepatide alone produces significant weight lossclinical trials show average reductions of 20-22% body weight over 68 weeksmaking additional lipotropic support potentially unnecessary for many patients
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