Hydration requirements increase during treatment
Dipeptidyl(amino)peptidase IV and post proline cleaving enzyme in cultured endothelial and smooth muscle cells
However, be careful not to overtrain without adequate recovery, as extreme physical stress can actually increase oxidative damage in the short term

Wegovy highlights of prescribing information, Food and Drug Administration (2024) FDAs concerns with unapproved GLP-1 drugs used for weight loss, Food and Drug Administration (2024) FDA alerts health care providers, compounders and patients of dosing errors associated with compounded injectable semaglutide products, Food and Drug Administration (2024) Alcohol and diabetes, American Diabetes Association (2024) Rybelsus highlights of prescribing information, Food and Drug Administration (2024) Food sources of dietary fiber, Dietary Guidelines for Americans (2024) Semaglutide injection, MedlinePlus (2024) FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize, Food and Drug Administration (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice
And weight gain is often driven by multiple factors: hormones, insulin resistance, medications, sleep deprivation, stress, and muscle loss