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Healthcare providers typically recommend optimizing tirzepatide dosing (up to 15 mg weekly for Zepbound) before adding other weight loss medications
The overall pattern is consistent: most gastrointestinal side effects peak during dose escalation, diminish within weeks, and become minimal at stable maintenance doses
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More severe conditions like gastric ulcers or duodenal ulcers may require 40mg daily for long periods of timee to treat ulcers effectively and prevent them from coming back
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