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doi: 10.1017/S0963180115000079

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

The anti-pharma industry position is understandable, with many scandals that have plagued the industry (such as Vioxx, Oxycontin, and several others) without any accountability of the companies or their senior management

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by increasing stomach acidity or liver enzyme elevations)