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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

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A similar plasma B12/holoTC ratio in patients with cancer and the controls suggests that the proportion of B12 bound to TCN1 to that bound to transcobalamin is unchanged in patients with cancer, thus both B12-binding proteins may be upregulated to the same extent

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When your cells are starved for usable B12, the levels of MMA and homocysteine in your blood go up