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No human randomized trial has pinned down a precise onset for BPC-157, so the ranges below come from preclinical research and clinical-practice observation

It cycles between reduced (GSH) and oxidized (GSSG) forms to preserve cellular oxidative homeostasis

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FOR DIARRHEA SOURCE: MedlinePlus

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD