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revealed that Convolvulus pluricaulis root extract effectively inhibited AChE activity in both adult and larval zebrafish, suggesting its utility in addressing cholinergic dysfunction in AD (Karunakaran et al., 2022)

This creates feed-forward cycles that exacerbate cuproptosis: mtROS oxidize cytosolic GSH, releasing bound Cu, and may upregulate the copper importer CTR1 via pathways such as NF-B, increasing copper influx [65]

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To provide further mechanistic insight into the role of IGF-1/IGF-1R in NK cell development, we investigated the levels of IRS-1 in human CD34 + cells cultured with either IL-15 or the combination of IL-15 and IGF-1 at 14 or 21 days and compared it with the levels of IRS-1 in 293A cells, which usually expressed normal levels of IRS-1

doi: 10.2174/1381612829666221219093450 18