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Most of the time, patients will not take these medications together

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Tirzepatide went further, with up to 20.9% weight reduction in the SURMOUNT-1 trial (Jastreboff et al., N Engl J Med, 2022)

Dosage, Administration, and Treatment Protocol Semaglutide is typically administered as a once-weekly injection under the guidance of a healthcare provider

To further assess their efficacy, we conducted a Mendelian randomization (MR) analysis to determine whether metformin and semaglutide, the highest- and lowest-ranking DM2 DMTs within the DM2-AD pathway comorbidity network identified through our network pharmacology approach, influence AD risk via genetic mechanisms