Head CT conducted using a CT scanner (Aquilion Lightning/Helios i Edition, Canon Medical Systems, Tochigi, Japan) showed occipital bone destruction at the lesion site (Figure 3)
Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms
Weight Suppression as a Key Risk Factor A central concept in the webinar was weight suppression , defined as the difference between a persons highest historical weight and their current weight
By reducing abdominal and visceral fat, patients often experience a more defined and sculpted physique
JAMA 2022;327(6):534e45
