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doi: 10.1080/09553002.2018.1484194 74 MathiasD.MitchelR

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

In the brains of Alzheimer's mouse model, genetic deletion of Fpn increased ferroptosis and then induced memory impairment, while restoring Fpn ameliorated ferroptosis and memory impairment ( GSH-dependent Pathway Glutathione peroxidase 4 (GPX4) is a selenium (Se)-containing enzyme, which plays a central role in the reduction of lipid ROS production

Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms