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NICE recommends the use of DPP-4 inhibitors as second-line therapy after metformin failure [HbA1c 6.5% (47.5 mmol/mol)] when SU use is either contraindicated or not tolerated, or there is a significant risk of hypoglycaemia or its consequences 52

Most patients experience significant improvement in nausea tolerance by weeks 612 of treatment, even as their doses increase

doi: 10.1023/a:1025635913927

Aim for the front or outer part of your upper thigh, steering clear of the inner thigh or bony areas where theres less subcutaneous tissue

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