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Many participants discontinued therapy at some point, and in most the episodes returned, later resolving again on renewed therapy

While no definitive causal relationship has been established in humans, these medications are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Treatment should not be stopped or restarted solely because of billing changes without discussing medication safety and dosing with the prescribing provider

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