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While the deleterious effects of uric acid-induced NO depletion and increased oxidative stress on EC function have been demonstrated (20,35-37), emerging evidence has suggested that high uric acid conditions may also affect VSMCs (38,39)

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Altogether, these studies suggest that both melatonin and treatments aimed to remodulate circadian homeostasis hold promise not only in enhancing treatment efficacy and quality of life, but also in potentially counteracting immunosuppressive and pro-metastatic mechanisms driven by circadian disruption in BC patients