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Extremely high temperatures have been shown to denature cytoskeletal proteins, leading to their abnormal distribution in the oocyte 12 , leading mitochondria to relocate to the cell periphery instead of maintaining a homogeneous distribution throughout the cytoplasm 67

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In granulosa cells of women with endometriosis, elevated lipid peroxidation markers such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) have been observed, accompanied by decreased glutathione (GSH) and glutathione peroxidase 4 (GPx4), key inhibitors of ferroptosis (32)

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