If sleep disturbances persist beyond the initial adjustment period (typically 48 weeks), further evaluation may be warranted to exclude other causes
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It is best to check with the gastroenterologists under those circumstances when one is having black stools that do not fade after a couple of days along with one or more worrying features
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However, validation studies have shown that hospital admission for cardiovascular events in the CPRD linked HES database has a high positive predictive value.4445 Although the recording of the components of serious renal events (for example, renal complications of diabetes, chronic kidney disease) has not been validated in the CPRD, we do not expect any outcome misclassification to be differential between the exposure groups