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( Diabetologia , 2023) characterised biased agonism at the GLP-1 receptor, dissecting differential G-protein versus -arrestin recruitment by semaglutide and its downstream effects on insulinotropic and anorectic signalling [5]

In addition, GLP-1 RAs liraglutide and semaglutide are indicated for weight management in people with obesity or overweight (Jensterle et al., 2022)