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Ruptured ferroptotic cells trigger innate immunity by releasing damage-associated molecular pattern molecules (DAMPs), such as heat shock proteins (HSPs) and oxidized lipids, upon tissue damage or tumor therapy ( Composed of B cells, T cells, and their secreted products, adaptive immunity is responsible for recognizing and clearing pathogens or abnormal cells specifically and forming immune memory ( 2.1 Macrophages Macrophages, which form a pivotal element of the innate immune system, are imperative for several facets of inflammatory processes, phagocytosis of debris, and tissue repair ( Figure 2 )

PMCID: PMC1552321

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Several studies have suggested that people with lupus tend to have lower levels of glutathione compared to healthy individuals

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2