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Compound 12 , when compared to allopurinol and febuxostat, also demonstrated good performance in Caco2 permeability, intestinal absorption, bloodbrain barrier penetration, and plasma protein binding, which suggests its good absorption and distribution capacity

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(2021) Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue: a systematic review, meta-analysis, and meta-regression

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This makes results more predictable and effective