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Notably, britanin (Bri), a sesquiterpene lactone extracted from Inula japonica, also reduces AMPK phosphorylation, downregulates SREBP1c expression, and alleviates hepatic oxidative stress and apoptosis by decreasing Caspase3 expression and the Bax/Bcl2 ratio, thereby mitigating NAFLD (Zhao et al., 2021)

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10.1016/s0015-0282(02)04813-6 Fertil