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As integral components of the NVU, perivascular astrocytes maintain BBB characteristics by contributing to basement membrane formation, regulating pericyte differentiation, and modulating EC functions by regulating the expression of TJs such as claudin-5, occludin, and ZO-1 [49, 51,52,53]

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These observations indicate that nanoformulations of ibuprofen or other NSAIDs can increase effectivity within the brain and at the same time minimalize the adverse peripheral side-effects [79]

Value of circulating cell-free DNA analysis as a diagnostic tool for breast cancer: a meta-analysis