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These mechanisms indicate that decrements in GLP-1R efficacy are not merely the result of receptor downregulation but are rooted in a fundamental disruption of the intracellular environment, driven by organelle stress and lipotoxic signaling

[DOI] [PMC free article] [PubMed] [Google Scholar] 292.Amorim J.A., Coppotelli G., Rolo A.P., Palmeira C.M., Ross J.M., Sinclair D.A

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