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HO-1 facilitates the breakdown of heme, resulting in the release of significant quantities of reactive iron ions, which then promote the Fenton reaction, ultimately producing lipid peroxides and causing ferroptosis in osteoblasts ( Figure 3 ) (124, 136)

Reduced inflammation prevents premature transition to catagen

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FIGURE 4 5.2 Ferroptosis and DOR Abnormalities in iron metabolism are associated with various degenerative diseases, and granulosa cells, oocytes, and their supporting cells in the ovary are particularly sensitive to OS (Stockwell et al., 2017)

The tissue effect of argon-plasma coagulation with prior submucosal injection (Hybrid-APC) versus standard APC: a randomized ex-vivo study